![]() ![]() Through her research, Davies is exploring whether the nature of planarian pluripotency changes throughout the life cycle and just how that pluripotency is maintained. What’s more, planarian PSCs can readily proliferate without causing the organism to age or develop cancer.ĬREDIT: MOL MIR, STOWERS INSTITUTE FOR MEDICAL RESEARCHĮrin Davies in her lab at Stowers Institute where she was a postdoc before coming to NIH. “The planarian has found a way to sustain embryonic pluripotency programs throughout life cycle,” Davies explained. In most animals (including mammals), however, PSCs are only present in embryos and are primarily responsible for the development of organs, limbs, and tissues. Planarians have adult pluripotent stem cells (PSCs) that fuel tissue homeostasis and regeneration. She applied to NIH’s competitive Earl Stadtman Investigator program and was hired by NIH in 2020 to work in NCI’s Cancer and Developmental Biology Laboratory, where she heads the Potency and Developmental Plasticity Section. When she finished her training, she was eager to continue that research in her own lab. ![]() mediterranea and was able to observe the cellular mechanisms that guide development through the planarian’s life cycle. Scale bar: 100 microns.ĭuring her postdoctoral training, she pioneered molecular and functional studies of embryogenesis in S. Embryogenesis lasts for approximately two weeks for this flatworm species. The blue belly button-like structure is the embryonic pharynx the small blue circles are undifferentiated embryonic cells. This image pictures a Stage 3 embryo of the flatworm Schmidtea mediterranea stained with riboprobes.
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